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In persons heterozygous for HbS (carriers of sickling haemoglobin), the polymerisation challenges are minimal, since the ordinary allele can create 50 percent of the haemoglobin. In folks homozygous for HbS, the presence of long-chain polymers of HbS distort the shape on the crimson blood cell from a smooth doughnut-like form to ragged and jam pack

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